Article
FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia.
Stem cells (Dayton, Ohio) - 1 May 2006
Parcells Bertrand W, Ikeda Alan K, Simms-Waldrip Tiffany, Moore Theodore B, Sakamoto Kathleen M
Abstract excerpt
Ligand-mediated activation of the FMS-like tyrosine kinase 3 (FLT3) receptor is important for normal proliferation of primitive hematopoietic cells. However, activating mutations in FLT3 induce ligand-independent downstream signaling that promotes oncogenesis through pathways involved in proliferation, differentiation, and survival. FLT3 mutations are identified as the most frequent genetic abnormality in acute...
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