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Article

No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations.

PLoS neglected tropical diseases - 1 Feb 2018

Kimuda Magambo Phillip, Noyes Harry, Mulindwa Julius, Enyaru John, Alibu Vincent Pius, Sidibe Issa, Mumba Ngoyi Dieuodonne, Hertz-Fowler Christiane, MacLeod Annette, Tastan Bishop Özlem, Matovu Enock

Abstract excerpt

BACKGROUND: Human African trypanosomiasis (HAT) manifests as an acute form caused by Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, particularly for APOL1. We have undertaken candidate gene association studies (CGAS) in a Ugandan Tbr and a Tbg HAT endemic area, to determine whether...

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Source

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Identifiers

PMID: 29470556
DOI: 10.1371/journal.pntd.0006300
PMCID: PMC5844566

Genes

APOL1
CGAS
CFH
HPR
IFNG
MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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