Article
CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus.
Autoimmunity - 1 Sept 2017
Salviano-Silva Amanda, Petzl-Erler Maria Luiza, Boldt Angelica Beate Winter
Abstract excerpt
Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different...
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