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Article

Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2017

Rajeshkumar N V, Yabuuchi Shinichi, Pai Shweta G, De Oliveira Elizabeth, Kamphorst Jurre J, Rabinowitz Joshua D, Tejero Héctor, Al-Shahrour Fátima, Hidalgo Manuel, Maitra Anirban, Dang Chi V

Abstract excerpt

Purpose: To identify effective metabolic inhibitors to suppress the aggressive growth of pancreatic ductal adenocarcinoma (PDAC), we explored the in vivo antitumor efficacy of metabolic inhibitors, as single agents, in a panel of patient-derived PDAC xenograft models (PDX) and investigated whether genomic alterations of tumors correlate with the sensitivity to metabolic inhibitors.Experimental Design: Mice with...

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Identifiers

PMID: 28611197
DOI: 10.1158/1078-0432.CCR-17-1115
PMCID: PMC6540110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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