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Article

Additive Cytotoxic and Colony-Formation Inhibitory Effects of Aspirin and Metformin on PI3KCA-Mutant Colorectal Cancer Cells.

International journal of molecular sciences - 15 May 2024

Gonçalves Joana, Pinto Sara, Carmo Francisca, Silva Cláudia, Andrade Nelson, Martel Fátima

Abstract excerpt

Human malignancies are one of the major health-related issues throughout the world and are anticipated to rise in the future. Despite huge investments made in anticancer drug development, limited success has been obtained and the average number of FDA approvals per year is declining. So, an increasing interest in drug repurposing exists. Metformin (MET) and aspirin (ASP) possess anticancer properties. This work...

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Identifiers

PMID: 38791419
DOI: 10.3390/ijms25105381
PMCID: PMC11121714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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