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The Pentamer glycoprotein complex inhibits viral Immediate Early transcription during Human Cytomegalovirus infections

18 Sept 2024

Abstract excerpt

The Pentamer complex of Human Cytomegalovirus (HCMV) consists of the viral glycoproteins gH, gL, UL128, UL130, and UL131 and is incorporated into infectious virions. HCMV strains propagated extensively in vitro in fibroblasts carry UL128, UL130, or UL131 alleles that do not make a functional complex and thus lack Pentamer function. Adding functional Pentamer to such strains decreases virus growth in fibroblasts....

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 39292744
DOI: 10.1073/pnas.2408078121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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