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Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system

10 Jun 2015

Abstract excerpt

Human cytomegalovirus (HCMV) causes significant disease worldwide. Multiple HCMV vaccines have been tested in man but only partial protection has been achieved. The HCMV gH/gL/UL128/UL130/UL131A complex (Pentamer) is the main target of neutralizing antibodies in HCMV seropositive individuals and raises high titers of neutralizing antibodies in small animals and non-human primates (NHP). Thus, Pentamer is a...

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PMID: 26058896
DOI: 10.1002/bit.25670

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