Regulation of myonuclear positioning and muscle function by the skeletal muscle-specific CIP protein

Abstract excerpt

Significance The arrangement of nuclei in myofibers, which are multinucleated skeletal muscle cells, is essential for their proper function. Abnormal nuclear positioning in myofibers is a common feature of several skeletal muscle diseases, including centronuclear myopathy and muscular dystrophy. Here, we show an isoform of the CIP protein (sk-CIP) contributes to the regulation of the positioning of nuclei in...

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