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Article

Gene-environment interaction on cognition: a twin study of childhood maltreatment and COMT variability.

Journal of psychiatric research - 1 Jul 2013

Goldberg Ximena, Fatjó-Vilas Mar, Alemany Silvia, Nenadic Igor, Gastó Cristobal, Fañanás Lourdes

Abstract excerpt

The functional variant Val(158)Met in the coding sequence of COMT gene is involved in the modulation of dopamine availability in the prefrontal cortex in both clinical and general population samples. It has been suggested that the interplay between this genotype and early environmental factors could be used to predict the observed variation in cognitive flexibility. However, other genetic variants and...

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Source

Identifiers

PMID: 23538286
DOI: 10.1016/j.jpsychires.2013.02.002

Genes

COMT

Provenance

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Gene-environment interaction on cognition: a twin study of childhood maltreatment and COMT variability.PMID 23538286Read ↗

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The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.Semantic proximity Read ↗

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Joint Impact of Early Life Adversity and COMT Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress.Semantic proximity Read ↗

The divergent impact of catechol-O-methyltransferase (COMT) Val158Met genetic polymorphisms on executive function in adolescents with discrete patterns of childhood adversity.Semantic proximity Read ↗

The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism.Semantic proximity Read ↗

Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.Semantic proximity Read ↗

Gene-Environment Interactions in Irrational Beliefs: The Roles of Childhood Adversity and Multiple Candidate Genes.Semantic proximity Read ↗

Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment.Semantic proximity Read ↗

COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence.Semantic proximity Read ↗

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