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Article

Cross-Tissue Exploration of Genetic and Epigenetic Effects on Brain Gray Matter in Schizophrenia.

Schizophrenia bulletin - 15 Feb 2018

Lin Dongdong, Chen Jiayu, Ehrlich Stefan, Bustillo Juan R, Perrone-Bizzozero Nora, Walton Esther, Clark Vincent P, Wang Yu-Ping, Sui Jing, Du Yuhui, Ho Beng C, Schulz Charles S, Calhoun Vince D, Liu Jingyu

Abstract excerpt

Closely linking genetics and environment factors, epigenetics has been of increasing interest in psychiatric disease studies. In this work, we integrated single nucleotide polymorphisms (SNPs), DNA methylation of blood and saliva, and brain gray matter (GM) measures to explore the role of genetic and epigenetic variation to the brain structure changes in schizophrenia (SZ). By focusing on the reported SZ genetic...

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PMID: 28521044
DOI: 10.1093/schbul/sbx068
PMCID: PMC5814943

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