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Article

Genetic polymorphisms of metabolic enzymes and the pharmacokinetics of indapamide in Taiwanese subjects.

The AAPS journal - 1 Mar 2014

Wang Teng-Hsu, Hsiong Cheng-Huei, Ho Hsin-Tien, Shih Tung-Yuan, Yen San-Jan, Wang Hui-Hung, Wu Jer-Yuarn, Kuo Benjamin Pei-Chung, Chen Yuan-Tsong, Ho Shung-Tai, Hu Oliver Yoa-Pu

Abstract excerpt

To understand the genetic makeup and impact on pharmacokinetics (PK) in the Taiwanese population, we analyzed the pharmacogenetic (PG) profile and demonstrated its effects on enzyme metabolism using indapamide as an example. A multiplex mass spectrometry method was used to examine the single nucleotide polymorphism (SNP) profile of eight major phases I and II metabolic enzymes in 1,038 Taiwanese subjects. A PG/PK...

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Identifiers

PMID: 24357089
DOI: 10.1208/s12248-013-9535-x
PMCID: PMC3933584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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