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Article

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway.

Journal of the American Society of Nephrology : JASN - 1 Jan 2010

Zhou Bo, Zhuang Jieqiu, Gu Dingying, Wang Hua, Cebotaru Liudmila, Guggino William B, Cai Hui

Abstract excerpt

WNK kinase is a serine/threonine kinase that plays an important role in electrolyte homeostasis. WNK4 significantly inhibits the surface expression of the sodium chloride co-transporter (NCC) by enhancing the degradation of NCC through a lysosomal pathway, but the mechanisms underlying this trafficking are unknown. Here, we investigated the effect of the lysosomal targeting receptor sortilin on NCC expression and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19875813
DOI: 10.1681/ASN.2008121275
PMCID: PMC2799281

Genes

WNK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway.PMID 19875813Read ↗

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells.Semantic proximity Read ↗

Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse modelsSemantic proximity Read ↗

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.Semantic proximity Read ↗

Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II.Semantic proximity Read ↗

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.Semantic proximity Read ↗

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.Semantic proximity Read ↗

Life and death of the distal nephron: WNK4 and NCC as major players.Semantic proximity Read ↗

DOPAMINE D4 RECEPTOR DOWN-REGULATES RENAL SODIUM CHLORIDE COTRANSPORTER VIA UBIQUITINATION-ASSOCIATED LYSOSOME DEGRADATIONSemantic proximity Read ↗

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.Semantic proximity Read ↗

Cellular mechanisms of WNK4-mediated regulation of ion transport proteins in the distal tubule.Semantic proximity Read ↗

CLN3 regulates endosomal function by modulating Rab7A activitySemantic proximity Read ↗

The evolving concepts of KS-WNK1 effect on NCC activity.Semantic proximity Read ↗

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