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Article

Phosphorylation regulates NCC stability and transporter activity in vivo.

Journal of the American Society of Nephrology : JASN - 1 Oct 2013

Yang Sung-Sen, Fang Yu-Wei, Tseng Min-Hua, Chu Pei-Yi, Yu I-Shing, Wu Han-Chung, Lin Shu-Wha, Chau Tom, Uchida Shinichi, Sasaki Sei, Lin Yuh-Feng, Sytwu Huey-Kang, Lin Shih-Hua

Abstract excerpt

A T60M mutation in the thiazide-sensitive sodium chloride cotransporter (NCC) is common in patients with Gitelman's syndrome (GS). This mutation prevents Ste20-related proline and alanine-rich kinase (SPAK)/oxidative stress responsive kinase-1 (OSR1)-mediated phosphorylation of NCC and alters NCC...

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Source

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Identifiers

PMID: 23833262
DOI: 10.1681/ASN.2012070742
PMCID: PMC3785268

Genes

OSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23833262-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Phosphorylation regulates NCC stability and transporter activity in vivo.PMID 23833262Read ↗

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