Article
The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein.
Protein science : a publication of the Protein Society - 1 Aug 2017
Woehl Jordan L, Ramyar Kasra X, Katz Benjamin B, Walker John K, Geisbrecht Brian V
Abstract excerpt
The extracellular adherence protein (Eap) plays a crucial role in pathogenesis and survival of Staphylococcus aureus by inhibiting the classical and lectin pathways of complement. We have previously shown that Eap binds with nanomolar affinity to complement C4b and disrupts the initial interaction between C4b and C2, thereby inhibiting formation of the classical and lectin pathway C3 pro-convertase. Although an...
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