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Endosomal trafficking of the EGFR mutant, EGFRvIII, results in exosomal secretion that triggers astrocyte reactivity

2019-10-11

Abstract excerpt

<title>Abstract</title> <p><underline>Background:</underline> The epidermal growth factor receptor (EGFR) variant three (EGFRvIII) mutation is linked with approximately one third of Glioblastoma Multiforme (GBM) tumors and is associated with poor patient prognosis. Persistent signaling due to a lack of the EGFR ectodomain and inefficient degradation have been suggested to underlie the tumorgenic properties of EGF...

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Literature Corpus work
83ef8cb6-0730-50f7-a6ba-c0a2f48e8268
DOI
10.21203/rs.2.15913/v1
Open publication

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Endosomal trafficking of the EGFR mutant, EGFRvIII, results in exosomal secretion that triggers astrocyte reactivityDOI 10.21203/rs.2.15913/v1
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