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Article

Exosomal transfer of miR-1238 contributes to temozolomide-resistance in glioblastoma

24 Mar 2019

Abstract excerpt

BACKGROUND: Although temozolomide (TMZ) resistance is a significant clinical problem in glioblastoma (GBM), its underlying molecular mechanisms are poorly understood. In this study, we identified the role of exosomal microRNAs (miRNAs) from TMZ-resistant cells as important mediators of chemoresistance in GBM cells. METHODS: Exosomes were isolated from TMZ-resistant GBM cells and characterized via scanning...

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PMID: 30917935
DOI: 10.1016/j.ebiom.2019.03.016

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