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Article

Colorectal cancer: how does it start? How does it metastasize?

Surgical oncology clinics of North America - 1 Oct 2000

Rodriguez-Bigas M A, Stoler D L, Bertario L, Anderson G R, Baba S

Abstract excerpt

Colorectal carcinogenesis is a multistep process with an apparently orderly progression from benign tissue to invasive malignancy and metastases. Yet at the genome level, a considerably more chaotic situation exists, with order arising through the process of natural selection in the midst of genomic instability. Major pathways for colorectal carcinogenesis begin with suppressor loss or acquisition of a mutator...

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PMID: 11008227

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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