A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.

doi:10.1371/journal.pone.0025227

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Article

A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis.

PloS one - 1 Jan 2011

Chou Yii-Her, Woon Peng Yeong, Chen Wei-Chiao, Hsu Yu-Wen, Chang Jer-Ming, Hwang Daw-Yang, Chiu Yi-Ching, Kuo Ho-Chang, Chang Wei-Pin, Hou Ming-Feng, Liu Mu-En, Chang Jan-Gowth, Chang Wei-Chiao

Abstract excerpt

Calcium nephrolithiasis is one of the most common causes of renal stones. While the prevalence of this disease has increased steadily over the last 3 decades, its pathogenesis is still unclear. Previous studies have indicated that a genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with the total serum calcium levels. In this study, we collected DNA samples from 480...

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PMID: 21966463
DOI: 10.1371/journal.pone.0025227
PMCID: PMC3178627

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CASR

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