Article
CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.
Environment international - 1 Aug 2017
Llop Sabrina, Tran Van, Ballester Ferran, Barbone Fabio, Sofianou-Katsoulis Aikaterini, Sunyer Jordi, Engström Karin, Alhamdow Ayman, Love Tanzy M, Watson Gene E, Bustamante Mariona, Murcia Mario, Iñiguez Carmen, Shamlaye Conrad F, Rosolen Valentina, Mariuz Marika, Horvat Milena, Tratnik Janja S, Mazej Darja, van Wijngaarden Edwin, Davidson Philip W, Myers Gary J, Rand Matthew D, Broberg Karin
Abstract excerpt
BACKGROUND: Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute to this varied response to MeHg. Studies in Drosophila have identified the cytochrome p450 3A (CYP3A) family as candidate MeHg susceptibility genes. OBJECTIVES: We evaluated whether genetic...
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