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Article

Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: A birth cohort study.

Neurotoxicology - 1 Sept 2020

Ponsonby Anne-Louise, Symeonides Christos, Saffery Richard, Mueller Jochen F, O'Hely Martin, Sly Peter D, Wardrop Nicole, Pezic Angela, Mansell Toby, Collier Fiona, Burgner David, Thompson Kristie, Vijayasarathy Soumini, Sugeng Eva J, Dwyer Terence, Ranganathan Sarath, Anderson Peter J, Anderson Vicki, Vuillermin Peter

Abstract excerpt

Prenatal phthalate chemicals may have adverse effects on brain development by various mechanisms including oxidant damage. However, birth cohort findings have been conflicting. This study aimed to (i) investigate the interplay between maternal prenatal phthalate levels, infant genetic vulnerability to oxidative stress, and child neurodevelopment and (ii) examine combined putative oxidant exposures. In a...

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Identifiers

PMID: 32479765
DOI: 10.1016/j.neuro.2020.05.006

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