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Article

Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish.

PloS one - 1 Jan 2017

Carvan Michael J, Kalluvila Thomas A, Klingler Rebekah H, Larson Jeremy K, Pickens Matthew, Mora-Zamorano Francisco X, Connaughton Victoria P, Sadler-Riggleman Ingrid, Beck Daniel, Skinner Michael K

Abstract excerpt

Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental exposure of zebrafish to MeHg is known to alter their neurobehavior. The current study investigated the direct exposure and transgenerational effects of MeHg, at tissue doses similar to those detected in exposed human populations, on sperm epimutations (i.e.,...

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Share to Behavior, Animal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

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Identifiers

PMID: 28464002
DOI: 10.1371/journal.pone.0176155
PMCID: PMC5413066

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