Article
UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner.
The Journal of cell biology - 5 Jun 2017
Ishikawa Tokiro, Toyama Takuya, Nakamura Yuki, Tamada Kentaro, Shimizu Hitomi, Ninagawa Satoshi, Okada Tetsuya, Kamei Yasuhiro, Ishikawa-Fujiwara Tomoko, Todo Takeshi, Aoyama Eriko, Takigawa Masaharu, Harada Akihiro, Mori Kazutoshi
Abstract excerpt
The unfolded protein response (UPR) handles unfolded/misfolded proteins accumulated in the endoplasmic reticulum (ER). However, it is unclear how vertebrates correctly use the total of ten UPR transducers. We have found that ER stress occurs physiologically during early embryonic development in medaka fish and that the smooth alignment of notochord cells requires ATF6 as a UPR transducer, which induces ER...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.