Article

Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum

2021-02-23

Abstract excerpt

<h4>ABSTRACT</h4> SEC24 is mainly involved in cargo sorting during COPII vesicle assembly. There are four SEC24 paralogs (A to D) in mammals, which are classified into two subgroups (SEC24A/B and SEC24C/D). Pathological mutations in SEC24D cause osteogenesis imperfecta with craniofacial dysplasia in humans. sec24d mutant fish also recapitulate the phenotypes. Consistent with the skeletal phenotypes, the secreti...

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Literature Corpus work: 34dc3a5f-e44d-55c7-892e-48ea98619dfd
DOI: 10.1101/2021.02.23.431880

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