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Article

Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells

9 May 2017

Abstract excerpt

Cancer cells may co-opt the NKG2D lymphocyte receptor to complement the presence of its ligands for autonomous stimulation of oncogenic signaling. Previous studies raise the possibility that cancer cell NKG2D may induce high malignancy traits, but its full oncogenic impact is unknown. Using epithelial ovarian cancer as model setting, we show here that ex vivo NKG2D + cancer cells have stem-like capacities, and...

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PMID: 28499126
DOI: 10.1016/j.neo.2017.03.005

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