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Article

Soluble NKG2D ligand promotes MDSC expansion and skews macrophage to the alternatively activated phenotype.

Journal of hematology & oncology - 20 Feb 2015

Xiao Gang, Wang Xuanjun, Sheng Jun, Lu Shengjun, Yu Xuezhong, Wu Jennifer D

Abstract excerpt

Expression of surface NKG2D ligand MIC on tumor cells is deemed to stimulate NK and co-stimulate CD8 T cell anti-tumor immunity. Human cancer cells however frequently adopt a proteinase-mediated shedding strategy to generate soluble MIC (sMIC) to circumvent host immunity. High levels of sMIC have been shown to correlate with advanced disease stages in cancer patients. The underlying mechanism is currently...

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Identifiers

PMID: 25887583
DOI: 10.1186/s13045-015-0110-z
PMCID: PMC4342005

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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