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Article

High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment.

Cell reports - 31 Aug 2021

Gonzalez Veronica D, Huang Ying-Wen, Delgado-Gonzalez Antonio, Chen Shih-Yu, Donoso Kenyi, Sachs Karen, Gentles Andrew J, Allard Grace M, Kolahi Kevin S, Howitt Brooke E, Porpiglia Ermelinda, Fantl Wendy J

Abstract excerpt

Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint blockade despite significant frequencies of exhausted T cells. Here we apply mass cytometry and uncover decidual-like natural killer (dl-NK) cell subpopulations (CD56+CD9+CXCR3+KIR+CD3-CD16-) in newly diagnosed HGSC samples that correlate with both tumor and transitioning epithelial-mesenchymal cell abundance. We show different...

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Source

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Identifiers

PMID: 34469729
DOI: 10.1016/j.celrep.2021.109632
PMCID: PMC8546503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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