Article

Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity

2024-01-30

Abstract excerpt

<h4>Background: </h4> Peripheral blood-derived natural killer (NK) cells spontaneously lyse tumor cells without prior sensitization. However, NK cells in peripheral blood (PBNK cells) are in a resting state and exhibit inhibitory phenotypes and impaired cytotoxicity. Thus, strengthening the cytotoxic effector function of PBNK cells and improving NK cell expansion in vitro for a convenient allogeneic therapy are es...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 33cb6a75-71fc-5e46-8d4b-70e8f20c572e
DOI: 10.22541/au.170664269.97077369/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activityDOI 10.22541/au.170664269.97077369/v1Read

Supercharged NK Cells Are a Unique Population of Cells Based on Transcriptomic, Single-Cell RNAseq, Proteomic, and Functional Characteristics; Comparison with Other NK Cell SubpopulationsSemantic proximity Read

Advantages and clinical applications of natural killer cells in cancer immunotherapy.Semantic proximity Read

Cell therapy could benefit from BCG: how anti-tumour BCG-primed NK cells selectively proliferate over other lymphocytes and efficiently kill cancer cellsSemantic proximity Read

Human NK cells and cancerSemantic proximity Read

Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors.Semantic proximity Read

Intrinsic and extrinsic factors determining natural killer cell fate: Phenotype and function.Semantic proximity Read

Multifaceted characterization of the biological and transcriptomic signatures of natural killer cells derived from cord blood and placental bloodSemantic proximity Read

Emerging insights into natural killer cells in human peripheral tissues.Semantic proximity Read

Human CD56bright NK Cells: An Update.Semantic proximity Read

Human natural killer cellsSemantic proximity Read

Natural Killer Cells: From Innate to Adaptive FeaturesSemantic proximity Read

High-Dimensional Single-Cell Analysis of Natural Killer Cell Heterogeneity in Human BloodSemantic proximity Read