Article
Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits.
BMC genomics - 20 Sept 2023
Cheng Youshu, Justice Amy, Wang Zuoheng, Li Boyang, Hancock Dana B, Johnson Eric O, Xu Ke
Abstract excerpt
BACKGROUND: Cocaine use (CU) is associated with psychiatric and medical diseases. Little is known about the mechanisms of CU-related comorbidities. Findings from preclinical and clinical studies have suggested that CU is associated with aberrant DNA methylation (DNAm) that may be influenced by genetic variants [i.e., methylation quantitative trait loci (meQTLs)]. In this study, we mapped cis-meQTLs for...
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