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Article

Cav1.3 (CACNA1D) L‐type Ca2+ channel dysfunction in CNS disorders

4 Feb 2016

Abstract excerpt

Abstract Cav1.3 belongs to the family of voltage‐gated L‐type Ca2+ channels and is encoded by the CACNA1D gene. Cav1.3 channels are not only essential for cardiac pacemaking, hearing and hormone secretion but are also expressed postsynaptically in neurons, where they shape neuronal firing and plasticity. Recent findings provide evidence that human mutations in the CACNA1D gene can confer risk for the development...

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PMID: 26842699
DOI: 10.1113/jp270672

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