Article
Perspectives of Gene Therapies in Autosomal Dominant Polycystic Kidney Disease.
Current gene therapy - 1 Jan 2017
Xu Yuchen, Li Ao, Wu Guanqing, Liang Chaozhao
Abstract excerpt
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease in the clinic. The predominant clinical manifestation is bilateral and progressive cysts formation in the kidneys, impairs normal renal parenchyma, and ultimately leads to endstage renal disease (ESRD). ADPKD is a heterogenic disease which is resulted from the mutations of PKD1 or PKD2 genes which encode...
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