Article
Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs.
Biochimica et biophysica acta - 1 Oct 2011
Tan Ying-Cai, Blumenfeld Jon, Rennert Hanna
Abstract excerpt
Autosomal dominant polycystic kidney disease (ADPKD) is a common, monogenic multi-systemic disorder characterized by the development of renal cysts and various extrarenal manifestations. Worldwide, it is a common cause of end-stage renal disease. ADPKD is caused by mutation in either one of two principal genes, PKD1 and PKD2, but has large phenotypic variability among affected individuals, attributable to PKD...
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