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Article

Genome-wide analysis of somatic copy number alterations and chromosomal breakages in osteosarcoma.

International journal of cancer - 15 Aug 2017

Smida Jan, Xu Hongen, Zhang Yanping, Baumhoer Daniel, Ribi Sebastian, Kovac Michal, von Luettichau Irene, Bielack Stefan, O'Leary Valerie B, Leib-Mösch Christine, Frishman Dmitrij, Nathrath Michaela

Abstract excerpt

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. It is characterized by highly complex karyotypes with structural and numerical chromosomal alterations. The observed OS-specific characteristics in localization and frequencies of chromosomal breakages strongly implicate a specific set of responsible driver genes or a specific mechanism of fragility induction. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28494505
DOI: 10.1002/ijc.30778

Genes

DLG2
LSAMP
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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