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Identification of the SUMO E3 ligase PIAS1 as a potential survival biomarker in breast cancer

11 May 2017

Abstract excerpt

Metastasis is the ultimate cause of breast cancer related mortality. Epithelial-mesenchymal transition (EMT) is thought to play a crucial role in the metastatic potential of breast cancer. Growing evidence has implicated the SUMO E3 ligase PIAS1 in the regulation of EMT in mammary epithelial cells and breast cancer metastasis. However, the relevance of PIAS1 in human cancer and mechanisms by which PIAS1 might...

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PMID: 28493978
DOI: 10.1371/journal.pone.0177639

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