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Article

Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas.

Stem cell reports - 13 Dec 2016

Bogachek Maria V, Park Jung M, De Andrade James P, Lorenzen Allison W, Kulak Mikhail V, White Jeffrey R, Gu Vivian W, Wu Vincent T, Weigel Ronald J

Abstract excerpt

Many solid cancers have an expanded CD44+/hi/CD24-/low cancer stem cell (CSC) population, which are relatively chemoresistant and drive recurrence and metastasis. Achieving a more durable response requires the development of therapies that specifically target CSCs. Recent evidence indicated that inhibiting the SUMO pathway repressed tumor growth and invasiveness, although the mechanism has yet to be clarified....

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Source

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Identifiers

PMID: 27916539
DOI: 10.1016/j.stemcr.2016.11.001
PMCID: PMC5161532

Genes

CD44
CD24
MMP14
TFAP2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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