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Article

Expression of <scp>FOXM</scp>1 and related proteins in breast cancer molecular subtypes

1 Apr 2016

Abstract excerpt

Forkhead box (FOX) proteins constitute an extended family of transcriptional regulators. FOXM1 is ubiquitously expressed in cells undergoing proliferation, and overexpression of FOXM1 is associated with poor prognosis in various malignant tumours. FOXM1 and FOXO3a are often transcriptionally antagonistic. FOXO3a plays a critical tumour-suppressive role in breast cancer. FOXO activity is modulated by its...

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PMID: 27277416
DOI: 10.1111/iep.12187

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