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Article

SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts

21 Oct 2024

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) are the most abundant stromal cellular component in the tumor microenvironment (TME). CAFs contribute to tumorigenesis and have been proposed as targets for anticancer therapies. Similarly, dysregulation of SUMO machinery components can disrupt the balance of SUMOylation, contributing to tumorigenesis and drug resistance in various cancers, including breast cancer....

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PMID: 39432155
DOI: 10.1007/s13402-024-01005-w

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