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Article

Transcription factor RBP-J-mediated signalling regulates basophil immunoregulatory function in mouse asthma model.

Immunology - 1 Sept 2017

Qu Shuo-Yao, He Ya-Long, Zhang Jian, Wu Chang-Gui

Abstract excerpt

Basophils (BA) play an important role in the promotion of aberrant T helper type 2 (Th2) immune responses in asthma. It is not only the effective cell, but also modulates the initiation of Th2 immune responses. We earlier demonstrated that Notch signalling regulates the biological function of BAin vitro. However, whether this pathway plays the same role in vivo is not clear. The purpose of the present study was...

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Identifiers

PMID: 28493549
DOI: 10.1111/imm.12753
PMCID: PMC5543508

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