Article
Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jun 2017
Agassandian Khristofor, Grobe Justin L, Liu Xuebo, Agassandian Marianna, Thompson Anthony P, Sigmund Curt D, Cassell Martin D
Abstract excerpt
Direct intracerebroventricular injection of angiotensin II (ANG II) causes increases in blood pressure and salt and water intake, presumably mimicking an effect mediated by an endogenous mechanism. The subfornical organ (SFO) is a potential source of cerebrospinal fluid (CSF), ANG I, and ANG II, and thus we hypothesized that the SFO has a secretory function. Endogenous levels of angiotensinogen (AGT) and renin...
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