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Article

Genetic knockdown of estrogen receptor-alpha in the subfornical organ augments ANG II-induced hypertension in female mice.

American journal of physiology. Regulatory, integrative and comparative physiology - 15 Mar 2015

Xue Baojian, Zhang Zhongming, Beltz Terry G, Guo Fang, Hay Meredith, Johnson Alan Kim

Abstract excerpt

The present study tested the hypotheses that 1) ERα in the brain plays a key role in the estrogen-protective effects against ANG II-induced hypertension, and 2) that the subfornical organ (SFO) is a key site where ERα mediates these protective actions. In this study, a "floxed" ERα transgenic mouse line (ERα(flox)) was used to create models in which ERα was knocked down in the brain or just in the SFO. Female...

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Identifiers

PMID: 25552661
DOI: 10.1152/ajpregu.00406.2014
PMCID: PMC4360069

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ANG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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