Article
Delayed maturation of catecholamine phenotype in nucleus tractus solitarius of rats with glial angiotensinogen depletion.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2003
Ogier Michael, Bezin Laurent, Cottet-Emard Jean-Marie, Bader Michael, Vincent Madeleine, Pequignot Jean-Marc, McGregor John, Bricca Giampiero
Abstract excerpt
Cerebral catecholamines and angiotensins are both involved in the regulation of cardiovascular function. Recent in vitro studies have suggested that angiotensin II modulates noradrenergic neurotransmission by controlling both the expression and neuritic trafficking of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. To assess the potential existence of such mechanisms in vivo, we...
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