Article
High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast.
Molecular medicine reports - 1 Jul 2017
Huang Yi, Chen Xiang, He Xiaofei, Guo Caifeng, Sun Xicui, Liang Fengyin, Long Simei, Lu Xilin, Feng Luyang, Guo Wenyuan, Zeng Yixuan, Pei Zhong
Abstract excerpt
Parkinson's disease (PD) is a common neurodegenerative disorder that affects ~2% of the human population aged >65. α‑synuclein serves a role in the pathogenesis of PD as it is a primary component of Lewy bodies, a pathological feature of PD. Endosomal‑lysosomal dysfunction may be a key factor involved in the pathophysiology of PD, and may cause PD‑associated neurodegeneration via α‑synuclein‑dependent and...
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