Article
Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice.
Neurobiology of learning and memory - 1 Jul 2017
Adeosun Samuel O, Hou Xu, Zheng Baoying, Melrose Heather L, Mosley Thomas, Wang Jun Ming
Abstract excerpt
BACKGROUND: LRRK2 G2019S mutation is associated with increased kinase activity and is the most common mutation associated with late-onset PD. However, the transgenic mouse model has not recapitulated cardinal PD-related motor phenotypes. Non-motor symptoms of PD including cognitive impairments are very common and may appear earlier than the motor symptoms. The objective of this study was to determine whether...
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