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Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.

Cancer cell - 8 May 2017

Spranger Stefani, Dai Daisy, Horton Brendan, Gajewski Thomas F

Abstract excerpt

Effector T cells have the capability of recognizing and killing cancer cells. However, whether tumors can become immune resistant through exclusion of effector T cells from the tumor microenvironment is not known. By using a tumor model resembling non-T cell-inflamed human tumors, we assessed whether adoptive T cell transfer might overcome failed spontaneous priming. Flow cytometric assays combined with...

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Identifiers

PMID: 28486109
DOI: 10.1016/j.ccell.2017.04.003
PMCID: PMC5650691

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CXCL9

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