Article

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

2021-05-27

Abstract excerpt

T cell-directed cancer immunotherapy often fails to generate lasting tumor control. Harnessing additional effectors of the immune response against tumors may strengthen the clinical benefit of immunotherapies. Here, we demonstrate that therapeutic targeting of the IFNγ-IL-12 pathway relies on the ability of a population of tissue-resident NK (trNK) cells to orchestrate an anti-tumor microenvironment. Particularly,...

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Literature Corpus work: 76ab976e-1e9e-5be1-ae62-58097025d2dd
DOI: 10.1101/2021.05.27.445981

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