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Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help

18 Apr 2023

Abstract excerpt

Abstract Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically engineered mouse pancreatic tumor models we demonstrate that tumor implantation generates a Trm niche that is dependent on direct antigen presentation by cancer cells. However, we observe...

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PMID: 37072485
DOI: 10.1038/s41598-023-33508-1

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