Article
Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2009
Liu Qiuyan, Zhang Chaoxiong, Sun Anna, Zheng Yuanyuan, Wang Li, Cao Xuetao
Abstract excerpt
Tumors can induce generation and accumulation of the immunosuppressive cells such as regulatory T cells in the tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell (DC)-based cancer vaccine can initiate antitumor immune response, regulatory DC subsets involved in the tolerance induction attracted much attention recently. Our previous studies demonstrate that the...
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