Article
Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jan 2024
Juan Thomas, Bellec Maëlle, Cardoso Bárbara, Athéa Héloïse, Fukuda Nana, Albu Marga, Günther Stefan, Looso Mario, Stainier Didier Y R
Abstract excerpt
Cardiac contractions and hemodynamic forces are essential for organ development and homeostasis. Control over cardiac contractions can be achieved pharmacologically or optogenetically. However, these approaches lack specificity or require direct access to the heart. Here, we compare two genetic approaches to control cardiac contractions by modulating the levels of the essential sarcomeric protein Tnnt2a in...
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