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Article

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.

Nature communications - 9 May 2017

Walsh Ryan M, Shen Erica Y, Bagot Rosemary C, Anselmo Anthony, Jiang Yan, Javidfar Behnam, Wojtkiewicz Gregory J, Cloutier Jennifer, Chen John W, Sadreyev Ruslan, Nestler Eric J, Akbarian Schahram, Hochedlinger Konrad

Abstract excerpt

PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored. Here, we have generated a Phf8 knockout allele in mice to examine the consequences of Phf8 loss for development and behaviour. Phf8 deficient mice neither display obvious...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Serotonin

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Source

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Identifiers

PMID: 28485378
DOI: 10.1038/ncomms15142
PMCID: PMC5436068

Genes

PHF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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