Article
New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary.
Antimicrobial agents and chemotherapy - 1 Jul 2017
Schweizer Inga, Blättner Sebastian, Maurer Patrick, Peters Katharina, Vollmer Daniela, Vollmer Waldemar, Hakenbeck Regine, Denapaite Dalia
Abstract excerpt
The Streptococcus pneumoniae clone Hungary19A-6 expresses unusually high levels of β-lactam resistance, which is in part due to mutations in the MurM gene, encoding a transferase involved in the synthesis of branched peptidoglycan. Moreover, it contains the allele ciaH232, encoding the histidine kinase CiaH (M. Müller, P. Marx, R. Hakenbeck, and R. Brückner, Microbiology 157:3104-3112, 2011,...
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