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Article

Heteroresistance to fosfomycin is predominant in Streptococcus pneumoniae and depends on the murA1 gene.

Antimicrobial agents and chemotherapy - 1 Jun 2013

Engel Hansjürg, Gutiérrez-Fernández Javier, Flückiger Christine, Martínez-Ripoll Martín, Mühlemann Kathrin, Hermoso Juan A, Hilty Markus, Hathaway Lucy J

Abstract excerpt

Fosfomycin targets the first step of peptidoglycan biosynthesis in Streptococcus pneumoniae catalyzed by UDP-N-acetylglucosamine enolpyruvyltransferase (MurA1). We investigated whether heteroresistance to fosfomycin occurs in S. pneumoniae. We found that of 11 strains tested, all but 1 (Hungary(19A)) displayed heteroresistance and that deletion of murA1 abolished heteroresistance. Hungary(19A) differs from the...

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Identifiers

PMID: 23571543
DOI: 10.1128/AAC.00223-13
PMCID: PMC3716182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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